Given the hidden danger of mis-operation and idle trip with a substation anti-maloperation smart-key in off-line operation mode, as well as the risk of an operator straying into a live bay, this paper develops an online anti-maloperation system integrated with a positioning system based on LoRa wireless communication and UWB-RTK positioning technology. Before the switching operation, the smart-key sends a rule verification request to the anti-maloperation host in real time through the LoRa communication link, and verifies operating results with the host after the switching operation. The positioning system collects location information through the integrated positioning terminal carried by the operator and shares it with the anti-maloperation host. When executing an operation ticket, the host can unlock or lock the operation permission of the smart-key by checking the match between the personnel and the location information of the operated device. The test results show that the system realizes the online monitoring and control of equipment, personnel and operation in the process of a switching operation, and can effectively reduce the safety risk.