The large-scale grid connection of wind power has affected the stable operation of the power system, and there are difficulties in consumption. In order to ensure the reliability of the wind power system, this paper proposes a rotating standby optimization configuration strategy that takes into account the demand response. Based on the analysis of wind power output and load forecasting error, this strategy considers the controllable load demand response capability and establishes a power supply optimization combination model with the minimum total system power generation cost as the goal. The model optimization is solved using the GUROBI solver. The simulation proves that the strategy can improve the economical operation of the power system under the premise of ensuring the stable operation of the power grid, enhance the ability of the conventional unit to provide rotary standby, and promote wind power consumption. It has high engineering applicability. This work is supported by Science and Technology Supporting Xinjiang Project of the Xinjiang Uygur Autonomous Region (No. 2017E0277) and Science and Technology Project of State Grid Corporation of China (No. SGGSKY00FJWT 1900165).