A distribution network partitioning method based on adaptive weighted Voronoi diagram is proposed for the uneven load distribution network after researching the application of conventional Voronoi diagram. According to the natural obstacles like roads, rivers, etc., this method divides the power supply regions into several grids and takes substation as the generator to spread around. The expansion speed represented as weight of generator in each direction is dynamically according to the substation load capacity, power supply distance, geographical barriers and management attribution to make the division more reasonable. The concept of virtual generator is introduced in order to achieve the coordination of the partition and urban planning and embody the continuity of distribution network development, and the problem of the partitions without power supply source is solved. An actual example is used to verify the validity and rationality of the proposed method.