With more and more distributed generations (DG) connecting into power grid, the problem of micro-grid with energy storage system and distribution network protection configuration is also more prominent, which are still being discussed at home and abroad. With the actual application of a micro-grid project, this paper analyzes the failure characteristics of distribution network and the internal micro-grid in the grid and off-grid mode. Real-time digital simulation system (RTDS) is used to build semi-physical simulation platform for simulation analysis, and the relay protection configuration method is elaborated with the simulation results, which has the guiding significance to the use of micro-grid.