The security and economy evaluation of closed loop point of distributed network considering uncertainty is studied, and then is applied in one actual distribution network. First, responding to the requirement of loop-closed operation of distribution metwork, a framework of security and economy evaluation of closed loop point is proposed. Secondly, taking into account the uncertainty of distribution network, a method of calculating the intervals of closed loop current and power loss is given based on interval theory, such then the scopes of closed loop current and power loss are made clear, respectively, providing a basis for the security and economy evaluation. Furthermore, a novel comparison method of interval number is put forward for comparing the intervals of closed loop current and power loss in probability. The two-level evaluation measure is also presented to synthesize the security and economy evaluation results, such that the optimal closed loop point of distribution network is chosen. Finally, the proposed method is applied in one actual distribution network, and the results show its feasibility and validity.