During the participation of wind turbine generators (WTGs) in primary frequency regulation, additional mechanical loads will be generated, affecting the safe and stable operation of the wind turbine. To clarify the impact mechanism of wind turbine participation in frequency regulation on mechanical loads, a mechanical structure dynamic model of WTGs containing integrated inertia control is established, and the influence of integrated inertia control on blade, tower and drivetrain loads is analyzed. Looking at torsional vibration of the drive shaft and lateral vibration of the tower excited by wind turbine participation in frequency regulation, first, using integrated inertia control, a method of dynamically adjusting the virtual inertia coefficient and droop coefficient according to the changes of wind turbine speed and frequency is proposed to improve the frequency regulation performance of WTGs. Secondly, a torsional vibration suppression strategy based on torque compensation is proposed to increase the equivalent damping and equivalent stiffness of the drivetrain. An electromechanical coupling simulation model of WTGs based on OpenFAST and Matlab is built. The results show that the proposed strategy can not only improve the frequency support capability of WTGs, but also reduce the additional mechanical loads on the drivetrain and tower during the frequency regulation process.