Since the fault characteristics of inverter-interfaced distributed generation (IIDG) are mainly determined by its control strategy and grid fault conditions, the traditional passive protection method suffers from difficulties in protection rectification and coordination in different fault scenarios and operating conditions. Thus an active distribution network active injection protection method based on control and protection coordination is proposed, in which the IIDG is controlled to actively inject characteristic signals into the grid during faults. The protection uses the detected characteristic signals to extract the fundamental information of the IIDG, thus eliminating the influence of the IIDG on each branch current and existing current protection. Since the fault features used by the protection are actively injected by the IIDG, the proposed method has good applicability in different scenarios and operating conditions, and does not require additional communication and detection equipment. This has the advantages of good economy and high practicality. The simulation results verify the effectiveness of the proposed method.