Intelligent stations have adopted optical fibers to transmit digital and analog signals, making the theory of secondary safety measures based on the “short current, off voltage, and split trip” method no longer suitable for such stations. To solve the problems of low efficiency and high error rate in traditional manual ticket preparation methods, an automatic generation technology of secondary safety measures based on a knowledge graph and substation configuration description (SCD) files is proposed. First, the technology builds a configuration database based on SCD files and a knowledge graph, and realizes the semi-automatic association between the virtual loop and the soft pressure plate according to the set rules. Second, from the compilation criteria of secondary safety measures in the intelligent station specifications, a safety measure rule library is constructed and the safety measures execution priority coding field is introduced. Finally, the automatic generation technology of secondary safety measures completes the rule matching of maintenance equipment secondary information based on the configuration database and safety measure rule library. This is used to automatically generate secondary safety measure tickets. The simulation results show that this technology can automatically and correctly generate secondary safety measure tickets based on on-site maintenance tasks, improve the efficiency of technical transformation, defect elimination, and verification in intelligent substations, and reduce the error rate of manual compilation. It provides a reference for achieving intelligent operation and inspection integration.