Aiming at the problems of long time consuming and low accuracy of existing fault location algorithms in distribution network with DG, a hierarchical model combined with an improved immune algorithm is proposed for distribution network fault location with DG. This paper simplifies the distribution network model, uses the improved immune algorithm to locate the fault area, and uses it again to locate the fault area again. The advantages of the proposed method are verified by analyzing single point fault and multi-point fault through experiment. The experimental results show that compared with the traditional fault location methods, the proposed method introduces the hierarchical theory, which effectively reduces the search dimension of fault nodes and has high fault location accuracy while ensuring the speed. This work is supported by the Science and Technology Project of State Grid Corporation of China (No. 5215F02000DA).