Because of the volatility and randomness of wind power, it is necessary for an integrated energy system in an electric heating area to have a certain flexibility to match the wind changes and reduce wind abandonment. Thermal load, whether in pipeline transmission or in building internal heating, has a certain thermal inertia, which means that the thermal load curve can be adjusted to a certain extent by wind electric fluctuation. This is an important means of flexible operation of a regional integrated energy system. In existing research, thermal inertia often changes within a predetermined range, and there is no theoretical guidance to deal with the fluctuation of thermal inertia in the system. This paper introduces the concept of user comfort, correlates thermal inertia with indoor and outdoor temperatures in real time, and proposes an optimal operation method of an electric heating zone integrated energy system based on the constraint of user comfort interval. Considering the indoor temperature balance of user comfort, an operational optimization model is established to minimize the total operating cost and wind abandonment penalty cost of the system with indoor heat dissipation as the control variable. An example is given to show that the proposed method can effectively reduce operating cost within the user's comfort zone and improve the wind abandonment capacity. This work is supported by the Science and Technology Project of State Grid Corporation of China (No. 2021YF-48).