With the development of integrated energy systems and energy markets, the realization of optimal energy allocation through market transactions has become a current research hotspot. Inter-regional energy interconnection has become a trend, and multi-regional energy transmission and trading can be realized. Taking distributed energy stations and multi-energy users as the main market participants, the operating principles and connection methods of interconnected distributed energy stations is studied first. And its mechanism model is established, and user bidding strategies are introduced to construct the framework of an energy retail market. Then, the differences in the trading mechanism of a double auction market in independent or interconnected regions are compared, and an energy retail market clearing strategy with the goal of maximizing the social surplus of regions is proposed. Finally, an integrated energy system is taken as an example to quantitatively analyze the results of market clearing and energy transmission on typical winter days, verifying that the proposed method can realize the optimal allocation of multi-regional resources and increase the total social surplus at each market clearing time. This work is supported by the National Natural Science Foundation of China (No. 51977141).