A distribution network reconfiguration method with high penetration of clean energy considering demand-side response is proposed. First, the distribution network reconfiguration model with high penetration of clean energy considering demand-side response is established. Its objective function is to minimize the comprehensive cost including the costs of network loss, abandonment of wind power and photovoltaic power, and switching operation. Then, for a non-convex model of distribution network reconfiguration, a mixed integer convex programming model (MISOCP) is obtained by introducing intermediate variables and performing second-order cone relaxation. This can avoid the global optimal solution while improving the solving efficiency. Finally, case studies are carried out on the improved IEEE 33-bus distribution network, and the influence of demand-side response and clean energy penetration rates on the reconfiguration results is analyzed. The results show that the distribution network reconfiguration method considering demand-side response can effectively improve the clean energy consumption capacity, smooth the load peak-to-valley difference, and improve the economy of network operation. This work is supported by the National Natural Science Foundation of China (No. 52177099).