The Combined Heat and Power (CHP) operation mode of ‘power determined by heat’ carries with it the problem of high operational cost and wind curtailment. To help tackle this we propose a multi-objective optimization scheduling method of a regional integrated energy system based on CHP flexible heat-to-electric ratio. First, the CHP is replenished with a fuel supply device, and the rate of replenishment at each period is flexibly adjusted to make the CHP heat-to-electric ratio follow the wind power output, so as to improve the wind power acceptance level and operational efficiency of the system. Then, a multi-objective optimization model of a regional integrated energy system is established based on comprehensive economy and environmental protection taking into account that the use of supplementary fuel increases system emissions, and the weight of each target is determined by an analytic hierarchy process. Finally, the mixed integer nonlinear programming problem is solved by commercial optimization software GAMS. Simulation results show the flexible adjustment of the CHP heat-to-electric ratio can effectively promote the integration of wind power and reduce system operating costs. However, the multi-objective optimization makes the CHP heat-to-electric ratio more advantageous than a single target, and it takes into account system economy and environmental protection. This work is supported by the National Natural Science Foundation of China (No. 51777027).