The 5G network, with its characteristics of wide coverage, high reliability and low delay communication, has a high application value in solving the ‘last kilometer’ problem in interconnection between the terminal equipment of a distribution network. To improve the practical level of distribution network protection based on standalone 5G, the communication resource requirements of distribution network protection are analyzed first. Then, given the overall structure of 5G distribution network protection, a more reliable time synchronization scheme is proposed through the same source transmission of clock signal and data signal. At the same time, differential protection and regional protection are applied in an urban distribution network. The differences between the two protection methods in overhead lines and cables are analyzed. The results show that overhead lines are recommended for regional protection, and cables can be compatible with differential protection and regional protection. This work is supported by the National Key Research and Development Program of China (No. 2016YFB0900100) and the Science and Technology Project of State Grid Corporation of China (No. 521904210087).