There is a problem of a multi-source network being accessed by distributed power sources and a difficulty in setting the coordination of staged over-current protection of a traditional distribution network. A solution for vertical connection and wide-area distribution network protection is proposed to realize the interphase of distribution network full-line quick action for short-circuit faults. Using 5G uRLLC high-reliability and low-latency network technology and a 5G communication power distribution terminal self-organizing network, fast peer-to-peer communication and networking solutions are proposed. Based on the exclusive end-to-end network networking mode of QoS+DNN+UPF, it effectively reduces the delay of the distribution network protection service and ensures the security of data transmission. The technology completed its first domestic pilot application in the Anhui Power Grid in 2019. Practice has proved that the proposed solution can effectively realize the precise location and isolation of distribution network faults, significantly improve the reliability of distribution network power supply, and has good practicability and application value. This work is supported by the General Project of National Natural Science Foundation of China (No. 51877060) and the Science and Technology Project of State Grid Anhui Electric Power Co., Ltd. (No. 52120018005C).