The access of distributed power in a modern distribution network makes it difficult for the traditional three-section current protection to meet the differential protection needs for the laying of optical fiber infrastructures, and its high construction cost makes its wide application difficult. The extreme data rates, ultra-low latency, and ultra-high reliability of 5G communication provide a new communication way for differential protection in a distribution network. This paper analyzes the technologies of 5G communication for differential protection, and the requirements for communication, and then proposes a solution based on a 5G wireless communication channel, SV sampling value message over UDP protocol, and sampling synchronization with a Beidou satellite navigation system. This solution has been verified in multiple 5G communication environments, showing that its differential protection performance meets distribution network requirements.