In order to effectively improve the reliability and safety of the overhaul, reconstruction and expansion process, this paper mainly builds an integrated communication simulation and analysis platform for substation safety isolation. According to the scale and configuration information of the primary system that ADPSS needs to simulate, this paper determines the method of describing the primary components and their configuration information with IEC61850 SCL. It also realizes a one-time simulation modeling configuration and the model correlation of the primary and secondary systems. The ADPSS test technology of dynamic closed-loop simulation is incorporated into the secondary system debugging and analysis framework based on the IEC61850 model configuration SCD file in the station. Based on the integrated communication simulation and analysis platform constructed, this paper presents a typical secondary system operating state switching scheme. By simulating the live operating state of the substation, it repeatedly tests the actual maintenance, modification, and replacement of secondary equipment to improve the reliability and safety of the overhaul and reconstruction process. This work is supported by National Key Research and Development Program of China (No. 2017YFB0902800) and Science and Technology Projects of Guizhou Power Grid Co., Ltd. (No. 0665002019030101BH00004).