To reduce the scale and frequency of blackouts in interconnected power grid, a control measure for interconnection power grid cascading failure based on heterogeneous cellular automata is proposed. Firstly, according to the fact that the interconnected power grid is composed of multiple regional power grids with different characteristics, and considering the interactions among regional power grids, the interconnection grid cascading failure model based on heterogeneous cellular automata is constructed. Then, considering the characteristics of each regional power grid and the interregional coordination relationship in different fault stages, a power flow control measure is proposed. Finally, taking IEEE118 node system as simulation case, the heterogeneous cellular automaton model is used to simulate the power failure. The effectiveness of the control measure is verified from the power law distribution and fault time series respectively, then its superiority is demonstrated by comparing it with other control measures. The simulation results show that the dispatcher can effectively reduce the blackout risk of regional power grids by reasonably selecting the interregional support coefficient according to the operation conditions of regional power girds. This work is supported by the Science and Technology Project of 2018 State Grid Corporation of China (No. XTB 17201800166) "Multi-Sand Pile Theory of Interconnection Power Grid Blackouts Early Warning Technology and System Development".