Ubiquitous Power Internet of Things (UPIoT) is the key to cope with the massive devices, data and application computing workloads of integration energy and cloud computing is key technique of UPIoT. Cloud data centers are the cores in cloud computing architecture, and cloud data center layout is crucial to cloud computing performance. Substations are core nodes of energy flow, application flow and information flow and have favorable resources for data center construction. The distributed architecture utilizes substation resources efficiently. Therefore, constructing multi-station integration distributed cloud data centers based on substations is an effective method to support UPIoT. Firstly, considering the relation of energy flow, application flow and information flow, substation characteristics are analyzed, and the distributed cloud computing architecture based on substations is proposed. Then, cloud data center layout optimization strategy for this architecture is presented. Finally, the strategy is analyzed by simulation based on case study and is proved effective. This work is supported by National Natural Science Foundation of China (No. 51577073) and Natural Science Foundation of Guangdong Province (No. 2016A030313476).