Aiming at the problem in conducting comprehensive evaluation and developing investment strategy of economic development zone distribution network in the early and middle stages of development, and considering the characteristics of the evaluation and the applicability of the indicators comprehensively, a comprehensive evaluation index system is constructed to evaluate the current development level of the distribution network of economic development zones and the investment benefit of the previous year. Meanwhile, an improved AHP-TOPSIS method which is applicable to evaluate single sample and can coordinate the balanced development of economy and security of distribution network is proposed. This method is based on the improved AHP method to obtain the weight, and the improved TOPSIS method is used to give the development status and level of each index in the evaluation index system more directly and clearly. Then, the index score and investment analysis are conducted respectively through the established rating standards of distribution network and the evaluation criteria of index investment priority. The practical application results show that the comprehensive evaluation index system can provide a relatively specific implementation plan for construction and development and investment strategy of the economic development zone, and can promote the development and improvement of the distribution network of the economic development zone more reasonably and efficiently. This work is supported by National High-tech R & D Program of China (863 Program) (No. 2015AA050101).