Aiming at the situation that it lacks of secondary equipment automatic positioning in intelligent substation local operation and maintenance and the device strap has no forced lockout, a method of local operation and maintenance for secondary equipment based on equipment self-locking technology is proposed. The method deploys an intelligent anti-misoperation module on the monitoring server, the anti-misoperation and lockout status of all operating objects inside of the substation is calculated in real-time through the combination of the substation information obtained from integrated business platform and rule library. By using the construction of smart substation secondary equipment spatial data model and the smart substation secondary equipment internet of things system based on electric power network, the secondary equipment self-positioning and recognizing function of the local operation and maintenance is established. Meanwhile, the anti-misoperation mechanism of interaction between the secondary and intelligent operation and maintenance anti-misoperation module is improved to achieve the secondary equipment positioning and operating object automatic lockout of the smart substation and get the local anti-misoperation double confirm mechanism. The method has achieved great effects during the actual project application, improved the security of the operation and maintenance and solved the doubts of the operation and maintenance personnel. This work is supported by Science and Technology Project of State Grid Corporation of China (No. 520530180015) “Research on the Third Generation of Intelligent Substation Auxiliary System”.