Optimal control strategy is one of the key technologies to improve the consumptive ability of distributed generations, which is also an important guarantee of safety, economy, efficiency and high quality during the operation of active distribution network. To solve the problems caused by high penetration of distributed generations, such as power flow direction change, voltage uplift, load unbalance, etc., this paper proposes a coordination optimization strategy which combines topology reconfiguration and multi-level reactive power compensation devices (under-load tap changer, bus capacitor, and feeder capacitor). A multi-objective optimization model based on active power loss, load balancing index and voltage deviation index is established. Through parameter adaptive adjustment and harmony memory library dynamic modification method, an improved multi-objective harmony search algorithm is proposed to solve this optimization model, which can greatly improve convergence speed and optimization ability of the algorithm. A number of experiments with IEEE 33 node test systems in different cases and scenarios are carried out, the computation speed and optimization performance of improved multi-objective harmony search algorithm and multi-objective harmony search algorithm, basic multi-objective harmony search algorithm are compared. The results show that the model and algorithm are feasible and effective. This work is supported by Science and Technology Project of State Grid Corporation of China (No. PD71-18-001) “Technical Research of Complex Distribution Network Modelling and Digit-mode Hybrid Simulation based on Cyber Physical Systems”.