In order to accurately evaluate the health status of mine hoist electric drive system, timely implement state maintenance, and ensure the safe and reliable operation of hoist system, a new method for status assessment of mine hoist electric drive system based on fuzzy synthetic evaluation is proposed. On the basis of the fault analysis of electric drive system components, an evaluation index system for operational status is constructed. The analytic hierarchy process method is applied to calculate the indicator weights and the degradation analysis is introduced in the standardization of the indicators. Finally, a multi-level fuzzy comprehensive evaluation of the hoist electric drive system of a mine model of JKMD-4′4(Z) in Henan province is carried out. The obtained results show that the applied system status assessment in this paper can precisely determine the operation state of the mine hoist electric drive system through simulation analysis. This work is supported by National Key Research and Development Program of China (No. 2016YFC0600906).