As the real time monitoring and control system of energy saving and emission reduction of regional generator sets involves many departments and heavy tasks, the traditional localization platform is difficult to effectively realize the complex functions. Combined with the development of information technology, this paper develops a real-time monitoring system based on cloud platform for energy saving and emission reduction. Firstly, the functional requirements of the energy saving and emission reduction system are introduced. Further research on the cloud platform of the energy saving and emission reduction system is studied. On the basis of analyzing the overall structure of the energy saving and emission reduction system based on cloud platform, this paper focuses on the core contents of cloud function, cloud structure and cloud security. And the design method of two key components of cloud platform acquisition system and master station system is designed. Finally, the application of the energy saving and emission reduction system in the regional power grid is introduced, and the effectiveness of the scheme is verified. This work is supported by Science and Technology Project of Tianjin Electric Power Company (No. KJ18-1-02).