Combined with the current situation of research and trial operation of local installation protection, a local installation application and operation and maintenance solution of entire substation is put forward. First, the specific business requirements of substation protection and automation are analyzed. Then the technical style of the whole station is unified, the secondary equipment localization solution for each business is put forward, and the whole substation's local installation secondary protection and control system is constructed. On this basis, this paper explores the local secondary equipment “factory debugging” and “replacement maintenance” operation means. After local installation secondary equipment solution of entire substation, the substation's overall protection function is improved and the automation function is highly integrated. The “factory debugging” and “replacement maintenance” operation means is more convenient and efficient for the debugging work and maintenance work in substation. This work is supported by Science and Technology Project of State Grid Zhejiang Electric Power Company (No. 5211UZ16000A).