The reliable operation of the relay protection equipment and its secondary circuit is an important factor to ensure the safety and stability of power grid. It is of great significance to improve the operation and maintenance efficiency of the relay protection equipment and its secondary circuit. In this paper, the design of relay protection intelligent mobile operation and maintenance management system based on power wireless virtual private network is elaborated, including the architecture of system and the deployment mode of communication network. In addition, information synchronization methods between the system and relay protection statistical analysis and operation management module, condition-based maintenance assistant decision-making module and some other system data modules are illustrated in detail. Through collection, collation, interaction and sharing of intelligent information in substation, the system realizes the purpose that equipment information are of mobile, paperless and standardized management and control, which can improve the convenience and efficiency of on-site operation and maintenance work and its management level, and as a result is quite significant to ensure the safety and stable operation of power grid. The system has been successfully applied in substation and achieved good results. This work is supported by Youth Fund of National Natural Science Foundation of China (No. 61602251) and Science and Technology Project of State Grid Corporation of China “Key Technology Research of Relay Protection Data Acquisition and Operation Analysis”.