This paper presents a design scheme for simulation test system based on smart substation local protection device, and verifies local protection function logic and secondary circuit’ validity and reliability using test cases automatically loaded by simulation test system. This simulation test system includes adaptive tester system, automatic test software, simulation control center, network equipment, etc. The adaptive tester hardware is based on a tester designed for flexible and customized output, which can output regular analog and SV message for 61850-9-2 protocol. The data transmission between the test system and the equipment under test is achieved by plug-and-play double-ended prefabricated navigation in the adaptive tester. The development of automatic test software is based on windows system with test cases for various types of protection device. In engineering application, the corresponding protection type is selected according to the protection device to be tested. It can adaptively load the corresponding test cases and flexibly check the test case entry for the number of test cases according to the specific circumstances of the project. This simulation test system is suitable for intelligent substation local protection factory testing, engineering joint debugging and expansion debugging. Automatic testing can improve the efficiency of testing, so it has good economic and social benefits. This work is supported by Science and Technology of Headquarter of State Grid Corporation of China (No. JSJX00YJJS1601932).