Taking into account the characteristics of multi-level management in active distribution network, this paper proposes an economic scheduling method of source-network-load multi-layer game based on game theory. In the active distribution network with multi-microgrids, in order to coordinate the relationship among the microgrids, distribution network and load, scheduling strategy is divided into three layers, which includes a cooperative game between microgrid and distribution network, a cooperative game between distribution network and a non-cooperative game between load and load respectively. The mutual reserve between the microgrid and the distribution network makes their cooperation be formed. The optimization of translational load can make the game among the load reach the Nash equilibrium. And the order variable is introduced to describe the scheduling priority. The multi-objective optimization scheduling model is established, which takes the minimum generation cost, minimum network loss and the maximum voltage deviation as the objectives. It is translated into a single objective based comprehensive weighting method, and the improved differential evolution algorithm is used to solve the problem. An example shows that the proposed method can improve the capacity of active distribution network to consume the renewable energy and the economy of system. This work is supported by National High-tech R & D Program of China (863 Program) (No. 2015AA0501022).