Aiming at the smart substation relay protection maintenance demand and the reason of misoperation, a smart anti-misoperation method of relay protection maintenance is proposed. The method takes active combining anti-misoperation technology as a basis, which combines the running state of primary equipment and secondary equipment to build the active safety mechanism which covers all device operations of the substation, and rejects any operation which can’t pass the anti-misoperation rules. It takes hard strap misoperate remediation technology as a supplement, which builds the risk warning system to monitor the state of hard straps by real time, and starts remediation measures to remove the risk factor. It takes safety measures maintenance technology as an auxiliary, which isolates the maintenance device through one button with high security and reliability. It takes device local anti-misoperation technology to build interactive anti-misoperation mechanism between the local device operation and monitoring system, which makes the anti-misoperation consistency come true. This method obtains good effects in smart substation, which is helpful to relay protection maintenance.