The secondary maintenance safety measures work exists a series of problems such as traditional manual create order is difficult, error-prone and inefficient, and safety measures order lacks of effective management in smart substation, etc. For these problems, a solution of the secondary maintenance safety measures visualization and one-touch operation system in smart substation is put forward. Based on integrated supervision and control system, the system realizes the functions of the secondary maintenance safety measures visual display, the smart create order, error proofing verification and simulation preview of the secondary maintenance safety measures order and the secondary equipment remote control operation order, the remote control operation of the operation order, the management of the safety measures order and the operation order, and log management. The realization and application of the system show that it improves the efficiency of the secondary operation and maintenance personnel, and ensures the effectiveness and correctness of the secondary maintenance safety measures work. For smart substation operation and maintenance, maintenance, and renovation work, it provides a safe and reliable technical support and application support system for the secondary maintenance safety measures implementation.