In traditional reliability analysis of distribution system and information system, their own characteristics are usually considered, but the mutual influence between them is always ignored. To evaluate the reliability of the distribution network considering the influence of the information system, this paper studies the relationship between the information system and the distribution system. And the influence of the information system malfunction to the working condition of the transformer, circuit breaker and standby power are analyzed emphatically. The sequential Monte Carlo method is used to simulate, and the process modes of the three kinds of components are modified. The influence of the power distribution system and the information system faults on the reliability of the distribution network is considered at the same time. A new reliability evaluation of the distribution network is proposed. Finally, the IEEE-RBTS Bus 6 system is taken as an example, and some influence factors of the distribution network reliability are obtained. According to the various influencing factors, some measures are put forward to enhance the reliability of the distribution network. This work is supported by Science and Technology Foundation of Chongqing (Research of Unified Data Acquisition and Centralized Monitoring Host Station for Distribution Network).