The integration of distributed generations (DG) into the distribution will become much more common. This paper introduces a distribution network reconfiguration method with the goal of minimizing the active power loss and considering the optimal active power dispatching of DGs. First, based on the power generation cost of DG, the optimization dynamic power dispatch of DGs is obtained with replicator dynamics (RG) based discretization’s algorithm. Then, the reconfiguration is realized with three optimization procedures. The preliminary optimization gets a local optimal solution based on MST algorithm. The secondary optimization gets the alternative optimal solution based on improved heuristic rules. And during the third procedure, the optimal solution can generally be obtained through correcting the results. The algorithm does not rely on the initial network topology. Combining the local optimal solution and the improved heuristic rules, the algorithm can significantly reduce the amount of the candidate switches needed to be evaluated. The modification can overcome the influence to the heuristic rules from loops and get the (approximate) optimal solution. Two typical test systems, i.e. 33-bus system and 69-bus system, verify the feasibility and effectiveness of the proposed method.