To ensure the normal operations of UHV transmission lines under strong wind and sand-dust conditions and the safety of transmission line and power grid, the prevention measures to encroachments by strong wind and sand-dust are presented in allusion to the 750 kV UHV transmission lines. Through summarizing the meteorological characteristics of Xinjiang region and analyzing the fault events that may occur in transmission lines of Xinjiang power grid under the effect of strong wind and sand-dust conditions, including the particular technical methods to prevent from shed skirt fracture of insulator, wear and tear of metal fittings and jumper conductors of UHV transmission lines, etc. Combining with some actual fault cases and the corresponding fault disposal measures of 750 kV transmission line in Xinjiang, it shows that this method is practical and effective in improving the ability of enduring strong wind and sand-dust conditions for 750 kV UHV transmission lines, and can be used in future design and provide valuable reference for transmission lines operating with high reliability in strong wind and sand-dust area.