Aiming at the shortcomings of current study of mutual impact on varied meteorological disasters on the overhead transmission line, a comprehensive evaluation on the impact degree of varied meteorological disasters on transmission line based on the proposed hierarchical analysis-entropy weight method is introduced. Where the subjective weight is determined by the analytic hierarchy, the objective weight is determined by the entropy weight method and the risk weight is determined by means of least square method, so the evaluation model for comprehensive operation risk of transmission line with risk weight, risk probability and risk consequence is established naturally. Finally, its feasibility is verified by applying it to transmission lines of some regional power network. This work is supported by National High-tech R & D Program of China (863 Program) (No. 2012AA050209 and No. 2011AA05A120).