Distribution network reconfiguration problem with distributed generation (DG) is known as a NP problem. To figure out this conundrum, mathematical programming is a good solution. A mixed integer second-order cone programming (MISOCP) model is proposed for the distribution network reconfiguration problem with DG. The model can be solved in polynomial time by using the interior point method. To build the MISOCP model, on-off states of switches and output states of DG are considered as decision variables; the linear weighted sum method is used to merge operating expenses and new energy loss into single objective; power flow constraint is transformed and slacked into second-order cone constraints, and the MISOCP model is developed. Finally, the results indicate that the performance of MISOCP method is better than that of other methods when solving the same problem. The results is benefit to the consumption of renewable energy, reduction of network loss and expenses when minimize the comprehensive cost.