Based on the "hierarchical, zoning, local control" system architecture, a multi-level wide-area intelligent protection and control system is constructed. Through the time synchronization method based on universal time coordinated and the synchronous phasor measurement technology, the precise time synchronization and real-time interaction of the information between the different substations in a region are realized. The protection method of wide-area current differential protection combined with comprehensive directional protection, wide-area adaptive backup automatic switchover technology and intelligent substation area protection technology are proposed. This system can realize the intelligent fault judgment, system decision and self-healing control of a regional power network. The successful application of two regional power grids in Duyun and Liupanshui of Guizhou province proves the practicality and reliability of the system.