In order to improve the accuracy and comprehensiveness of the power grid intelligent anti-misoperation result, this paper proposes switch unit model and loop topology search algorithm for intelligent topological anti-misoperation computing under the operating mode of integrated dispatching and control system. Basing on topological model and knowledge base of anti-misoperation rules, the system uses and/or tree reasoning and topological anti-misoperation computing method, and achieves the functions such as electromagnetic loop closing and equipment overload. This paper establishes the topological anti-misoperation model of a regional grid with this method, and implements the application based on anti-misoperation rules expert database. Site operation shows that, integrated anti-misoperation checking methods based on switch unit anti-misoperation model and anti-misoperation rules expert database can provide accurate verification results for preventing scheduling mistake, remote control by mistake and misoperation, and thus can ensure the safety of the power grid operation.