Contra posing to the insufficiency and problems existing in the traditional relay protection setting and coordination calculation management model, this paper develops a set of relay protection setting and coordination calculation process management system applicable to provincial, prefecture and county levels dispatching system. The system is based on the SOA and seamlessly integrates all the functions of the relay protection setting calculation related modules on the unified data platform, realizing the examination, approval and implement of the closed loop management of drawing of protection, and the basic data of protection setting calculation such as equipment parameters’ remote filling, parameter calculation modeling, protection setting calculating and auto-generating relay protection setting value notification model. This system has been successfully used in the relay protection setting calculation for the Yunnan Electric Power Grid’s provincial, prefecture and county levels dispatching system.