Ensemble empirical mode decomposition (EEMD) can accurately decompose the signal with noise. It overcomes the shortcomings of empirical mode decomposition (EMD) which can cause the frequency aliasing and false mode in decomposing the signal. TLS-ESPRIT algorithm itself has good noise cancellation capability and can accurately identify the parameters of the signal. A good method is proposed to detect harmonic and inter-harmonic through the use of the advantages of EEMD and TLS-ESPRIT. It determines the real harmonic and inter-harmonic by energy of each order component decomposed by EEMD. Simulation results show the feasibility and effectiveness of the method.