In order to connect DG to distribution network more reasonably, a new method of DG planning considering the variation of the distribution network structure is put forward. Firstly, this paper uses the loss sensitivity factor to get the optimal layout of DG. To minimize the system loss, the comprehensive optimization model is built to configure the network reconstruction and DG capacity. Secondly, the improved bacterial foraging algorithm is used to solve the proposed model. Finally, the IEEE33 and IEEE69’s node system are used for simulation calculation. The calculation results indicate that the DG planning considering the variation of the distribution network structure is more practical and effective.