In order to reduce the power loss of photovoltaic plants and to avoid utmostly the phenomena of collapse, hot spot damage and too fast natural aging rate, a new method is proposed by using the law of nature to realize a comprehensive intelligent management of PV modules. This method uses the I-V character of crystalline silicon and the law of nature to achieve the data of capacity output in theory and in reality, respectively, and then to estimate whether the PV modules are regular. Some experiments show that this method is good enough to fully meet the requirement of the accuracy of capacity output of PV modules and to effectively realize the comprehensive intelligent management of PV modules of large and medium-sized photovoltaic plants.