To meet the requirement of the distribution measure and control instrument’s communication function, this paper designs the protocol and accomplishes the communication between the intelligent instrument and the master station. The communication protocol referring to the IEC870-5-101 protocol has been drawn up. Moreover, using MFC of VC++, accomplished the interface of the master and child station, the operation to database and the communication between the master and child station. This system can achieve the functions such as data set-up, data query, unsetting the child station and tele-control. It will be widely applied in industrial field because of its outstanding performance.